|
KMID : 1134820120410030339
|
|
Journal of the Korean Society of Food Science and Nutrition
2012 Volume.41 No. 3 p.339 ~ p.344
|
|
|
Anti-diabetic Activity of Germinated Ilpum Rough Rice Extract Supplement in Mice
|
|
Lee Youn-Ri
Woo Koan-Sik
Hwang In-Guk
Kim Hyun-Young
Lee Sang-Hoon
Kim Yun-Bae
Lee Jun-Soo
Jeong Heon-Sang
|
|
|
Abstract
|
|
|
|
This study was performed to investigate the effect of germinated Ilpum rough rice extract on blood glucose in C57BL/KsJ-db/db mice. The mice were divided into several groups: normal control (NC), diabetic control (DC), those fed with 0.25% germinated Ilpum rough rice extract (DM-0.25%GIRRE), those fed with 0.5% germinated Ilpum roughrice extract (DM-0.5%GIRRE) and those fed with 1% germinated Ilpum rough rice extract (DM-1%GIRRE). After 8 weeks of treatment, body weight, water intake, and diet intake of the DM-1%GIRRE group were significantly lower than the other DM groups. Blood glucose levels of the DM-1%GIRRE group were significantly lower compared to the DC group. Fasting blood glucose HbA1c level and total glucose tolerance test were significantly lower in the DM-1%GIRRE groups compared to the DC group. There was no significant difference in serum insulin level among each group. Therefore, the results of this study demonstrate that germinated Ilpum rough rice extract alleviates many of the symptoms of diabetes in genetically obese mice and may offer a possibility as a therapeutic supplement for the normalization of blood glucose levels in humans with hyperglycemia. It may also have beneficial effects in patients with non-insulin-dependent diabetes mellitus.
|
|
|
KEYWORD
|
|
|
germinated Ilpum rough rice extract, blood glucose level, HbA1c level, serum insulin l
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|